alexa Discovery of potent, orally bioavailable, selective 5-HT1A B D receptor antagonists.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Genetic Syndromes & Gene Therapy

Author(s): Ward SE, Eddershaw PJ, Scott CM, Gordon LJ, Lovell PJ,

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Abstract 5-HT1 receptor antagonists have been discovered with good selectivity over the 5-HT transporter. This is the first report of highly potent, selective ligands for the 5-HT1A/B/D receptors with low intrinsic activity, which represent a useful set of molecules for further understanding the roles of the 5-HT1 receptor subtypes and providing new approaches for the treatment of depression. This article was published in J Med Chem and referenced in Journal of Genetic Syndromes & Gene Therapy

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