alexa Disease-related expression of the IL6 STAT3 SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis.
Surgery

Surgery

Surgery: Current Research

Author(s): Li Y, de Haar C, Chen M, Deuring J, Gerrits MM,

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Abstract BACKGROUND: Mouse models have shown that interleukin (IL)6 stimulates survival, proliferation and progression to cancer of intestinal epithelial cells via activation of signal transducers and activators of transcription 3 (STAT3). OBJECTIVE: To investigate the expression of IL6/phosphorylated STAT3 (p-STAT3)/suppressor of cytokine signalling 3 (SOCS3) in biopsy specimens from patients with ulcerative colitis (UC) and UC-related colorectal cancer (CRC) progression. METHODS: Biopsy specimens from patients with inactive UC (n=18), active UC (n=28), UC with low-grade dysplasia (LGD) (n=9), UC with high-grade dysplasia (HGD) (n=7), UC-CRC (n=11) and sporadic CRC (n=14) were included. Biopsy specimens (n=9) from patients without colonic abnormalities served as control. The protein expression of IL6, p-STAT3 and SOCS3 was determined immunohistochemically. RESULTS: Patients with active UC had significantly more IL6 and p-STAT3-positive epithelial cells than both patients with inactive UC and controls (strong positive IL6: 53.6\%, 11.1\% and 0\%, respectively; p-STAT3: 64.3\%, 22.2\% and 11.1\%, respectively; all p
  • DOI: 10.1136/gut.2009.184176
  • This article was published in Gut and referenced in Surgery: Current Research

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