alexa Disposition of marbofloxacin in vulture (Gyps fulvus) after intravenous administration of a single dose
Geology & Earth Science

Geology & Earth Science

Journal of Geography & Natural Disasters

Author(s): GarciaMontijano M, Waxman S, de Lucas JJ, Luaces I, de San Andrs MD

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The pharmacokinetics properties of marbofloxacin were studied in adult Eurassian Griffon vulture after single-dose intravenous (IV) administration of 2mg/kg. Drug concentration in plasma was determined by high-performance liquid chromatography and the data obtained were subjected to compartmental and non-compartmental kinetic analysis. Marbofloxacin presented a volume of distribution at steady-state (Vdss) of 1.51±0.22L and total plasma clearance (Cl) of 0.109±0.023L/hkg. The permanence of this drug was long in vultures (T(1/2)(λ)=12.51±2.52h; MRT(∞)=13.54±2.29h). The optimal dose of marbofloxacin estimated is 2.73mg/kg per day for the treatment of infections in vultures with MIC(90)=0.2μg/mL.

This article was published in Res Vet Sci and referenced in Journal of Geography & Natural Disasters

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