alexa Dissolution of pulp tissue by aqueous solution of chlorhexidine digluconate and chlorhexidine digluconate gel.
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): Okino LA, Siqueira EL, Santos M, Bombana AC, Figueiredo JA

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Abstract AIM: To evaluate the activity of various root canal irrigants on bovine pulp tissue. METHODOLOGY: The irrigants tested were: 0.5, 1.0 and 2.5\% sodium hypochlorite; 2\% aqueous solution of chlorhexidine digluconate; 2\% chlorhexidine digluconate gel (Natrosol); and distilled water as control. Bovine pulp fragments were weighed and placed in contact with 20 mL of each tested substance in a centrifuge at 150 r.p.m. until total dissolution. Dissolution speed was calculated by dividing pulp weight by dissolution time. Statistical analysis was performed using the Kruskal-Wallis test. RESULTS: Distilled water and both solutions of chlorhexidine did not dissolve the pulp tissue within 6 h. Mean dissolution speeds for 0.5, 1.0 and 2.5\% sodium hypochlorite solutions were 0.31, 0.43 and 0.55 mg min(-1), respectively. The solvent ability of chlorhexidine solutions was similar to that of distilled water. The results for sodium hypochlorite solutions, chlorhexidine solutions and distilled water were statistically different (P>0.01). CONCLUSIONS: Both chlorhexidine preparations and distilled water were not able to dissolve pulp tissue. All sodium hypochlorite solutions were efficient in dissolving pulp tissue; the dissolution speed varied with the concentration of the solution.
This article was published in Int Endod J and referenced in Journal of Antivirals & Antiretrovirals

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