alexa Distribution, function, and properties of leptin receptors in the brain.


Journal of Alzheimers Disease & Parkinsonism

Author(s): Funahashi H, Yada T, Suzuki R, Shioda S

Abstract Share this page

Abstract Leptin, a peptide hormone, is implicated in the modulation of food intake and maintenance of energy balance in many vertebrates including humans. It is considered to act via its receptor mainly through several hypothalamic nuclei that play critical roles in the regulation of appetite. This article looks mainly at the functional significance of leptin in rat brain by drawing on published reports of morphological and physiological analyses. Our immunohistochemical observations indicate that the leptin receptor is distributed throughout the brain, including the hypothalamus, and interestingly, is found in the hippocampus and neocortex. Physiological experiments with single living cells isolated from fresh rat hypothalamus clearly demonstrate that leptin has a significant effect on feeding-regulating neurons in the hypothalamus. Studies to date support a role for leptin not only in modulating food intake and appetite in rats and humans, but also in relation to learning and memory processes.
This article was published in Int Rev Cytol and referenced in Journal of Alzheimers Disease & Parkinsonism

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version