alexa Distribution of Lutein and Zeaxanthin Stereoisomers in the Human Retina
Ophthalmology

Ophthalmology

Journal of Clinical & Experimental Ophthalmology

Author(s): Bone RA, Landrum JT, Friedes LM, Gomez CM, Kilburn MD

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The distribution of macular pigment stereoisomers in the human retina has been mapped and a pathway to account for the presence of the non-dietary carotenoid,meso-zeaxanthin, is proposed. Adult neural retinas were cut into three concentric areas centered on the fovea, and the extracted carotenoids were analysed and purified by high-performance liquid chromatography. The dicarbamate or dibenzoate derivatives of the collected zeaxanthin fractions for each tissue sample were further analysed by HPLC to determine their stereoisomer composition. Whole retinas from infant eyes were similarly analysed. The results show that, relative to zeaxanthin, the concentration of lutein in the adult neural retina increases with radial distance from the fovea while that ofmeso-zeaxanthin decreases. Infant retinas were found to have more lutein and lessmeso-zeaxanthin, relative to zeaxanthin, than adult retinas. Small quantities of (3S, 3′S)-zeaxanthin were also found in the adult retina, particularly in the macula. It is proposed that lutein and zeaxanthin are transported into an individual's retina in the same proportions found in his or her blood serum. Some of the lutein is then converted intomeso-zeaxanthin, primarily in the macula, by a mechanism which is less developed in infants than adults.

This article was published in Experimental Eye Research and referenced in Journal of Clinical & Experimental Ophthalmology

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