alexa Distribution of the antiseptic resistance genes qacA, qacB and qacC in 497 methicillin-resistant and -susceptible European isolates of Staphylococcus aureus


Clinical Microbiology: Open Access

Author(s): Susanne Mayer, Mechthild Boos, Andreas Beyer, Ad C Fluit, FranzJosef Schmitz

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Methicillin-resistant Staphylococcus aureus (MRSA) is considered a major bacterial pathogen, because it is resistant to a variety of antibiotics and causes nosocomial infections worldwide. In clinical practice, one of the important hygienic measures used to prevent its spread is the decontamination of potentially contaminated rooms, utensils and colonized patients. It is alarming, therefore, that S. aureus isolates carrying antiseptic resistance genes have been isolated from clinical samples. Three determinants, the qacA, qacB and qacC genes, have been identified that confer resistance to organic cations by means of proton motive force-dependent multidrug efflux.

This article was published in J Antimicrob Chemother and referenced in Clinical Microbiology: Open Access

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