alexa Diurnal variation and dispersion in QT interval in cirrhosis: relation to haemodynamic changes


Journal of Anesthesia & Clinical Research

Author(s): Hansen S, Mller S, Bendtsen F, Jensen G, Henriksen JH

Abstract Share this page

BACKGROUND/AIMS: A long QT(C) interval has been described in a substantial fraction of patients with cirrhosis, but information on QT variation and dispersion is sparse. The aim was to determine QT variation with time and QT dispersion (QT(disp)).

METHODS: The study population comprised 23 patients with cirrhosis, undergoing a haemodynamic investigation. 24-h 12 lead Holter monitoring provided information on QT and heart rate variability.

RESULTS: Mean QT(C) was above upper normal limit (440 ms(1/2)) in eleven patients (47%) and significantly higher than in controls (441 vs 400 ms(1/2), p<0.01). The minimum value of QT(C) (but not the maximum value) showed a significant diurnal variation both in cirrhosis and controls. QT(disp) in cirrhosis and controls was similar (33 vs 36 ms, ns), but related to indicators of liver dysfunction, central circulation time, and arterial blood pressure (r=0.44-0.58, p=0.03-0.001). No diurnal variation of QT(disp) was found in cirrhosis. Heart rate variability was reduced with a significant relation to central hypovolaemia (r=0.55, p=0.01).

CONCLUSIONS: Twenty-four hours QT(C) is prolonged in a substantial fraction of patients with cirrhosis, but with normal diurnal variation. The combination of long QT(C) and normal QT(disp) suggests delayed myocyte repolarisation on the cellular level, rather than temporal and spatial heterogeneity in the myocardial wall.

This article was published in J Hepatol and referenced in Journal of Anesthesia & Clinical Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version