alexa DNA demethylation in PD-1 gene promoter induced by 5-azacytidine activates PD-1 expression on Molt-4 cells.


Journal of Clinical & Cellular Immunology

Author(s): Zhang M, Xiao XQ, Jiang YF, Liang YS, Peng MY,

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Abstract The expression of the programmed death 1 (PD-1) gene is an indicator of exhausted T-cells with decreased activation and function. It remains unknown, however, whether the methylation status of the PD-1 gene promoter is associated with PD-1 expression level. This study shows the changes of PD-1 expression levels and the demethylation status of the PD-1 promoter region in Molt-4 cells under different concentrations of 5-azacytidine (5-Zac). The result demonstrated that DNA demethylation at PD-1 promoter may contribute to PD-1 overexpression. Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved. This article was published in Cell Immunol and referenced in Journal of Clinical & Cellular Immunology

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