alexa DNA methylation as a pathogenic event and as a therapeutic target in AML
Pathology

Pathology

Journal of Clinical & Experimental Pathology

Author(s): Schoofs T, MllerTidow C

Abstract Share this page

DNA methylation and its influence on gene expression are key in understanding cancer pathogenesis. Even though it is becoming clear that DNA methylation strongly interacts with other components of the epigenetic machinery such as histone modifications, aberrant DNA methylation can still be regarded as a crucial hallmark of cancer by itself. In Acute Myeloid Leukemia (AML), aberrations of DNA methylation also rank among the most frequent alterations observed. Recent studies revealed that specific patterns of DNA methylation characterize AML and help to distinguish AML subtypes. The contribution of this epigenetic dysregulation to leukemogenesis in AML is currently unclear. However, interactions between mutated transcription factors and epigenetic networks have already been shown to be partially responsible for leukemic transformation, for e.g. in acute promyelocytic leukemia (APL). Also, direct mutations in the epigenetic master regulators EZH2 and DNMT3A were recently identified in AML and in diseases leading to secondary leukemia. These findings strengthen the view that dysregulated epigenetic networks can induce AML. Correspondingly, epigenetic therapies e.g. hypomethylating drugs show significant activity in AML. While benefit is observed in many patients, DNA hypomethylating therapy by itself is not curative. Furthermore, it is not clear whether the drugs' effects are solely epigenetic in nature since in vitro studies suggest different mechanisms of action. Current clinical trials aim to improve efficacy of DNA hypomethylating drugs for e.g. by combination with standard AML chemotherapy. Taken together, targeting the epigenetic machinery seems to be the way towards more effective therapies in AML.

This article was published in Cancer Treat Rev and referenced in Journal of Clinical & Experimental Pathology

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]line.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords