alexa Do macrophage innate immune receptors enhance atherogenesis?
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Clinical & Experimental Pharmacology

Author(s): Gordon S

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Abstract Macrophages play a central role in both innate immunity to infection and atherosclerosis. Castrillo and colleagues report that selected microbial agonists for Toll-like receptors strongly inhibit LXR-mediated cholesterol efflux from macrophages. TLR-LXR crosstalk could explain how nonspecific microbial infections promote atherogenesis.
This article was published in Dev Cell and referenced in Journal of Clinical & Experimental Pharmacology

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