alexa Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication.


Journal of Sleep Disorders & Therapy

Author(s): Comings DE, Muhleman D, Gysin R

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Abstract Subjects on an addiction treatment unit who had been exposed to severe combat conditions in Vietnam were screened for posttraumatic stress disorder (PTSD). Of 24 with PTSD, 58.3\% carried the D2A1 allele. Of the remaining eight who did not meet PTSD criteria, 12.5\% carried the D2A1 allele (p = 0.04). In a replication study of 13 with PTSD, 61.5\% carried the D2A1 allele. Of the remaining 11 who did not meet criteria for PTSD, 0\% carried the D2A1 allele (p = 0.002). For the combined group 59.5\% of those with PTSD carried the D2A1 allele versus 5.3\% of those who did not have PTSD (p = 0.0001). These results suggest that a DRD2 variant in linkage disequilibrium with the D2A1 allele confers an increased risk to PTSD, and the absence of the variant confers a relative resistance to PTSD. This article was published in Biol Psychiatry and referenced in Journal of Sleep Disorders & Therapy

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