Author(s): Thanos PK, Habibi R, Michaelides M, Patel UB, Suchland K,
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Abstract In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R(+/+)), both heterozygous (D4R(+/-)) and knockout (D4R(-/-)) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine. Published by Elsevier B.V.
This article was published in Behav Brain Res
and referenced in Journal of Alcoholism & Drug Dependence