alexa Dose-response study of topical minoxidil in male pattern alopecia.
Dermatology

Dermatology

Hair Therapy & Transplantation

Author(s): Shupack JL, Kassimir JJ, Thirumoorthy T, Reed ML, Jondreau L

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Abstract Fifty-eight men with Hamilton scale type III vertex or type IV male pattern baldness were studied to determine the dose-response activity of low concentrations of topical minoxidil in promoting hair growth. The patients were treated with topical minoxidil at doses of 0.01\%, 0.1\%, 1\%, or 2\% or placebo in a randomized double-blind design for 6 months. At the end of 6 months, patients using 0.1\%, 1\%, and 2\% topical minoxidil solutions showed a significantly greater difference in the mean increase of nonvellus hair growth in comparison with those using 0.01\% minoxidil or placebo. There was a clear dose-response correlation for the increase of nonvellus hairs in the 0.1\%, 1\%, and 2\% minoxidil treatment groups. There was a statistically significant difference in patient's self-evaluation of overall hair growth and degree of decreased hair shedding in the 1\% and 2\% minoxidil groups when compared with the other study groups. From this study we conclude that significant increases in nonvellus hair counts occur with 0.1\% and greater doses of minoxidil. However, only in patients treated with the 1\% and 2\% solutions of minoxidil was there clinically perceptible hair growth.
This article was published in J Am Acad Dermatol and referenced in Hair Therapy & Transplantation

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