Author(s): Boy R, Neto JG, Vargas FR, Fontana C, Almeida JC,
Abstract Share this page
Abstract A clinical follow up of 165 Down Syndrome (DS) patients in an outpatient clinic programme at the Centro de Genética Médica (IFF - FIOCRUZ) was undertaken retrospectively. Clinical and laboratorial investigations were performed, such as cytogenetics and hematological analysis, thyroid hormones survey, abdominal ultrasound and cervical column X Rays. The clinical diagnosis of Down Syndrome was mostly performed during the first year of life, and 70\% of all patients were under 4 years of age, being predominantly males. Trisomy 21 derived from non disjunction was found in 85\% of the patients. The most common congenital malformation was cardiopathy (37.5\%) and among all the clinical complications, repeated pneumonia could be evidenced in 30\% of the patients, mainly during the first year of life. Leukopenia was observed in 14\% of the patients and abdominal ultrasound scans allowed the early detection of biliary stones in 4.3\% of the patients examined, a significative finding in the paediatric population. A prospective clinical programme aiming to anticipate the detection of clinical complications on at risk DS populations will fulfill its objectives and may act as a reducing factor in the infantile mortality rate.
This article was published in J Pediatr (Rio J)
and referenced in