alexa Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation.


Archives of Surgical Oncology

Author(s): Jie Zhang, Pengxing He, Yong Xi, Meiyu Geng, Yi Chen, Jian Ding

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G9a, a histone methyltransferase, is aberrantly expressed in some human tumor types. By comparing 182 paired colorectal cancer and peritumoral tissues, we found that G9a was highly expressed in colorectal cancer (CRC). Overexpression of G9a promoted CRC cells proliferation and colony formation, whereas knockdown of G9a inhibited CRC cells proliferation. Depletion of G9a increased the rate of chromosome aberration, induced DNA double strand breaks and CRC cells senescence. G9a inhibition synergistically increased γH2AX expression induced by topoisomerase I inhibitors and ultimately led to CRC cell death. The findings that down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation may define G9a as potential oncotarget in CRC.

This article was published in Oncotarget and referenced in Archives of Surgical Oncology

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