Author(s): Fujita M, Ye Q, Ouchi H, Harada E, Inoshima I,
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Abstract The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.
This article was published in Antimicrob Agents Chemother
and referenced in Journal of Nutritional Disorders & Therapy