alexa DREADDs: novel tools for drug discovery and development.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Bioequivalence & Bioavailability

Author(s): Lee HM, Giguere PM, Roth BL

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Abstract Since the invention of the first designer receptors exclusively activated by designer drugs (DREADDs), these engineered G protein-coupled receptors (GPCRs) have been widely applied in investigations of biological processes and behaviors. DREADD technology has emerged as a powerful tool with great potential for drug discovery and development. DREADDs can facilitate the identification of druggable targets and enable researchers to explore the activities of novel drugs against both known and orphan GPCRs. Here, we discuss how DREADDs can be used as novel tools for drug discovery and development. Copyright © 2013 Elsevier Ltd. All rights reserved.
This article was published in Drug Discov Today and referenced in Journal of Bioequivalence & Bioavailability

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