alexa Drug delivery to the posterior segment of the eye III: the effect of parallel elimination pathway on the vitreous drug level after subconjunctival injection.
Biomedical Sciences

Biomedical Sciences

Journal of Biomolecular Research & Therapeutics

Author(s): Lee TW, Robinson JR

Abstract Share this page

Abstract The aim of the current study was to study the effect of a parallel elimination pathway on the vitreous drug level after simple injection and application of a zero-order release system by computer simulation. It was found that this pathway gives rise to an early peak time regardless of the physicochemical properties of the applied drug. In addition, the parallel elimination pathway is the major determinant of the vitreous drug level after simple subconjunctival injection. For a zero-order release system, release rate is not the only determinant of pharmacokinetics due to the parallel elimination pathway and k13 also plays a significant role in determining steady-state drug levels. The findings of the current study is necessary for the proper design of a drug delivery system for vitreal drug delivery through subconjunctival injection. This article was published in J Ocul Pharmacol Ther and referenced in Journal of Biomolecular Research & Therapeutics

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords