alexa Drug-induced depression: a systematic review to inform clinical practice.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Patten SB, Barbui C

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Abstract BACKGROUND: Certain medications may contribute to the etiology of depressive symptoms and disorders. Research in this area, however, has been hampered by methodological and conceptual problems. This review had two objectives: to identify evidence linking medical drugs to depressive symptoms and disorders, and to summarize this evidence in a clinically meaningful way. METHODS: Electronic literature searches were performed and studies were reviewed with reference to critical methodological features. RESULTS: No medications causing the typical major depressive syndrome were identified. Evidence was found linking corticosteroids, interferon-alpha, interleukin-2, gonadotropin-releasing hormone agonists, mefloquine, progestin-releasing implanted contraceptives and propranolol to the etiology of atypical depressive syndromes. CONCLUSIONS: A small number of drugs have been shown capable of inducing depressive symptoms. Drug-induced depression appears to differ symptomatically from classical major depression. Copyright 2004 S. Karger AG, Basel This article was published in Psychother Psychosom and referenced in Journal of Addiction Research & Therapy

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