Author(s): Verestiuc L, Ivanov C, Barbu E, Tsibouklis J
Abstract Share this page
Abstract The synthesis and characterisation of semi-interpenetrating polymeric networks obtained by the radical-induced polymerisation of N-isopropylacrylamide in the presence of chitosan using tetraethyleneglycoldiacrylate as the crosslinker is described. The influence of the degree of crosslinking and that of the ratio of chitosan to poly(N-isopropylacrylamide) on the "pH/temperature induced" phase transition behaviour and swelling characteristics of the hydrogel system are investigated. The ability of the same system to act as a controlled release vehicle for pilocarpine hydrochloride is evaluated.
This article was published in Int J Pharm
and referenced in Journal of Biomedical Engineering and Medical Devices