alexa Dynamic control of chiral space in a catalytic asymmetric reaction using a molecular motor.
Engineering

Engineering

Journal of Biosensors & Bioelectronics

Author(s): Wang J, Feringa BL

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Abstract Enzymes and synthetic chiral catalysts have found widespread application to produce single enantiomers, but in situ switching of the chiral preference of a catalytic system is very difficult to achieve. Here, we report on a light-driven molecular motor with integrated catalytic functions in which the stepwise change in configuration during a 360° unidirectional rotary cycle governs the catalyst performance both with respect to activity and absolute stereocontrol in an asymmetric transformation. During one full rotary cycle, catalysts are formed that provide either racemic (R,S) or preferentially the R or the S enantiomer of the chiral product of a conjugate addition reaction. This catalytic system demonstrates how different molecular tasks can be performed in a sequential manner, with the sequence controlled by the directionality of a rotary cycle. This article was published in Science and referenced in Journal of Biosensors & Bioelectronics

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