alexa Dynamin, a membrane-remodelling GTPase.
Neurology

Neurology

Journal of Multiple Sclerosis

Author(s): Ferguson SM, De Camilli P, Ferguson SM, De Camilli P

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Abstract Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events. The use of complementary approaches, including live-cell imaging, cell-free studies, X-ray crystallography and genetic studies in mice, has greatly advanced our understanding of the mechanisms by which dynamin acts, its essential roles in cell physiology and the specific function of different dynamin isoforms. In addition, several connections between dynamin and human disease have also emerged, highlighting specific contributions of this GTPase to the physiology of different tissues.
This article was published in Nat Rev Mol Cell Biol and referenced in Journal of Multiple Sclerosis

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