alexa Dyspepsia in HIV-infected patients under highly active antiretroviral therapy.
Gastroenterology

Gastroenterology

Journal of Gastrointestinal & Digestive System

Author(s): WerneckSilva AL, Prado IB

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Abstract BACKGROUND AND AIM: Upper gastrointestinal symptoms, mainly dyspepsia, are common adverse effects in patients under highly active antiretroviral therapy (HAART). Whether it is worthwhile to perform endoscopy early in their treatment is a matter of debate. We have done a prospective study of the prevalence and the etiology of endoscopic lesions in a large cohort of dyspeptic adult HIV-infected patients under HAART, according to their immunological status. METHODS: 528 (334 men and 194 women, mean age 38) HIV-infected patients under HAART with epigastric pain and/or nausea and vomiting underwent upper endoscopy. Patients were classified in two groups, according to CD4 cells counting (>200 cells/mm(3) or < or =200 cells/mm(3)). Gastric and duodenal biopsies were taken from normal mucosa and any lesion found. RESULTS: Gastric mucosa alterations were seen in 61.74\% of patients (40.71\% erythema, 18.38\% erosion and 2.65\% ulcer). Duodenum mucosa alterations were seen in 25.37\% of patients, mainly erosions (19.50\%) and ulcer (3.59\%). There was no difference in endoscopic findings according to CD4 cell count groups. Chronic active gastritis was shown in 459 patients (86.93\%). H. pylori infection was seen in 32.38\%, and it was more prevalent in the group with CD4 > 200 (p < 0.01). Opportunistic infections and malignancies were seen exclusively in patients with CD4 < or = 200. CONCLUSIONS: Most of the endoscopic lesions in dyspeptic HIV-infected patients under HAART were not related to AIDS. Upper endoscopy was more helpful in dictating clinical treatment in patients with low CD4 counts (< or =200) and should be done earlier in this group. This article was published in J Gastroenterol Hepatol and referenced in Journal of Gastrointestinal & Digestive System

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