alexa Early caffeine therapy and clinical outcomes in extremely preterm infants.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Patel RM, Leong T, Carlton DP, VyasRead S

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Abstract OBJECTIVE: To determine if early caffeine (EC) therapy is associated with decreased bronchopulmonary dysplasia (BPD) or death, decreased treatment of patent ductus arteriosus (PDA), or shortened duration of ventilation. STUDY DESIGN: In a retrospective cohort of 140 neonates ≤1250 g at birth, infants receiving EC (initiation <3 days of life) were compared with those receiving late caffeine (LC, initiation ≥3 days of life) using logistic regression. RESULT: Of infants receiving EC, 25\% (21/83) died or developed BPD compared with 53\% (30/57) of infants receiving LC (adjusted odds ratio (aOR) 0.26, 95\% confidence interval (CI) 0.09 to 0.70; P<0.01). PDA required treatment in 10\% of EC infants versus 36\% of LC infants (aOR 0.28, 95\%CI 0.10 to 0.73; P=0.01). Duration of mechanical ventilation was shorter in infants receiving EC (EC, 6 days; LC, 22 days; P<0.01). CONCLUSION: Infants receiving EC therapy had improved neonatal outcomes. Further studies are needed to determine if caffeine prophylaxis should be recommended for preterm infants. This article was published in J Perinatol and referenced in Pharmaceutica Analytica Acta

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