alexa Early outcomes of HIV exposed children in the first district-wide programme using extended regimens for the prevention of mother-to-child transmission of HIV, in Yaounde, Cameroon.


Journal of Antivirals & Antiretrovirals

Author(s): Njom Nlend AE, Same Ekobo C, Bitoungui M JR, Bagfegue Ekani B, Tchokoteu P,

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Abstract OBJECTIVE: Report on the early outcomes achieved in the prevention of mother-to-child transmission (PMTCT) programme in the Djoungolo Health District using more effective antiretroviral PMTCT regimens. METHODS: Observational cohort of HIV exposed infants. MAIN OUTCOME MEASURE: early infant HIV status and 3-month mortality rate. RESULTS: From March 2008 to March 2010, 587 HIV-positive mother-baby pairs were enrolled and classified according to the following maternal antiretroviral regimen: Group 1: highly active antiretroviral therapy (HAART), Group 2: dual therapy, Group 3: no treatment. 484/587 (82\%) underwent HIV-early infant diagnosis at a median age of 7 weeks; 4.5\% (95\% CI 2.65-6.34) were HIV-infected. HIV transmission rate differed by maternal prophylaxis: 1.7\% for HAART, 2.7\% for dual therapy and 15.7\% for Group 3 (p < 0.001), but not by feeding method (2.74\%)-exclusive breastfeeding vs. 5.34\% formula (NS). The 3-month mortality rate stands at 1\%. CONCLUSIONS: The 4.5\% MTCT-rate of HIV-1 reported, confirms the feasibility and effectiveness of a district wide PMTCT programme using HAART in low-income settings. This article was published in J Trop Pediatr and referenced in Journal of Antivirals & Antiretrovirals

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