alexa Early prediction of preeclampsia in high-risk women.


Journal of Clinical & Cellular Immunology

Author(s): Shaker OG, Shehata H

Abstract Share this page

Abstract BACKGROUND: The purpose of this study was to determine the role of the combined use of uterine artery Doppler velocimetry (UADV) and maternal serum placental growth factor (PlGF), vascular endothelial growth factor receptor-1 soluble fms-like tyrosine kinase-1 also called soluble (sVEGFR-1), and nitric oxide (NO) products concentrations for the prediction of preeclampsia in high-risk women and to compare these parameters between patients with mild and severe preeclampsia. METHODS: Patients at risk of preeclampsia (n=112) were subclassified as having either severe (n=38), mild (n=17), or no preeclampsia (n=57). Blood samples were obtained between 22 and 26 weeks of gestation. Doppler ultrasound of the uterine arteries was done at the time of blood sampling. Maternal serum PlGF and sVEGFR-1 concentrations were determined with enzyme-linked immunosorbent assay (ELISA). Nitric oxide colorimetric assay was used also to measure NO products in the maternal blood. RESULTS: Among patients with abnormal UADV, maternal serum sVEGFR-1, PlGF, and NO product concentrations contributed significantly in the identification of patients destined to develop mild and severe preeclampsia. sVEGFR-1 (pg/mL) concentration followed by NO product concentration (μmol/L) were found to be the best predictors for preeclampsia, with high sensitivity and specificity, followed by PlGF (pg/mL). CONCLUSIONS: Abnormal UADV and high concentrations of sVEGFR1 combined with low concentrations of PlGF and NO products may be used to predict the development of preeclampsia. This article was published in J Womens Health (Larchmt) and referenced in Journal of Clinical & Cellular Immunology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version