alexa Early randomized intervention with high-frequency jet ventilation in respiratory distress syndrome.
Pulmonology

Pulmonology

Journal of Pulmonary & Respiratory Medicine

Author(s): Carlo WA, Siner B, Chatburn RL, Robertson S, Martin RJ

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Abstract To determine whether early use of high-frequency jet ventilation reduces neonatal mortality or pulmonary morbidity rates, we randomly selected 42 infants with clinical and radiographic evidence of severe respiratory distress syndrome to receive either high-frequency jet ventilation or conventional ventilation. Separate sequential analyses (two-sided, alpha = 0.05, power = 0.95 to detect 85:15 advantage) were performed for mortality rates, air leaks, bronchopulmonary dysplasia, intraventricular hemorrhage, and assignment crossover, and a combined analysis was performed, with death overriding other outcome variables. Enrollment was completed when the combined analysis reached the sequential design boundary indicating no treatment difference. Mortality rates (19\% among infants receiving high-frequency jet ventilation vs 24\% among infants receiving conventional ventilation), the incidence of air leaks (48\% vs 52\%), bronchopulmonary dysplasia (39\% vs 41\%), and intraventricular hemorrhage (33\% vs 43\%), and assignment crossovers (14\% vs 24\%) did not differs significantly between the treatment groups. We conclude that early use of high-frequency jet ventilation does not prevent or substantially reduce mortality or morbidity rates associated with assisted ventilation.
This article was published in J Pediatr and referenced in Journal of Pulmonary & Respiratory Medicine

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