alexa Effect of acid blue 80, an anthracenedione dye, on rainbow trout liver, gill and gut cells in vitro.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Developing Drugs

Author(s): Tee PN, Wong YT, Sherry JP, Bols NC, Tee PN, Wong YT, Sherry JP, Bols NC

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Abstract Acid Blue 80 (AB80) is a dark blue colorant that like other synthetic dyes can get into the environment. Cultures of rainbow trout cell lines were dosed with AB80 either directly, which involved mixing AB80 stock solution into the medium over cells, or indirectly, which involved replacing the medium in cultures with medium that had AB80. A dose-dependent decline in cell viability was found in cultures with or without fetal bovine serum (FBS) after direct dosing. However, for FBS cultures, indirect dosing caused no loss of viability over 24h and in the long term was detrimental to RTgill-W1 but not RTL-W1 cultures. After 6 days at 50mg/L cytotoxicity was evident and by 9 days RTgill-W1 cell number had declined. Yet AB at 1mg/L elicited no changes over 9 days in any cell line. AB80 appears to have the potential to be toxic at only very high concentrations. Copyright © 2011 Elsevier Inc. All rights reserved. This article was published in Ecotoxicol Environ Saf and referenced in Journal of Developing Drugs

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