Author(s): Hirabayashi Y, Shimizu R
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Abstract We have investigated the effect of age on thoracic extradural dose requirements in 62 patients aged 20-79 yr. Fifteen millilitre of 2\% mepivacaine was administered at a constant rate (1 ml s-1) by syringe pump through an extradural needle at the T9-10 interspace. A mean of 15.5 (SD 4.2) spinal segments were blocked 15 min after completion of the administration. The extradural dose requirement decreased with increasing age (r = -0.7, P < 0.001), the requirement in the elderly (60-79 yr) being about 40\% smaller than that in young adults (20-39 yr).
This article was published in Br J Anaesth
and referenced in Journal of Anesthesia & Clinical Research