alexa Effect of antioxidants on glucose metabolism and plasma lipids in HIV-infected subjects with lipoatrophy.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): McComsey G, Southwell H, Gripshover B, Salata R, Valdez H, McComsey G, Southwell H, Gripshover B, Salata R, Valdez H

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Abstract Ten HIV-infected nucleoside reverse transcriptase inhibitor-treated subjects with lipoatrophy or sustained hyperlactatemia were given antioxidants: vitamins C, E, and N-acetyl cysteine. After 24 weeks, anthropometrics did not change significantly, except for a modest decrease in the waist-to-hip ratio. Fasting low-density lipoprotein cholesterol trended toward lower values. Fasting glucose significantly increased along with a significant increase in homeostatic model assessment values, reflecting an increase in insulin resistance. Controlled trials are required to evaluate directly the effects of these agents on lipid and glucose metabolism.
This article was published in J Acquir Immune Defic Syndr and referenced in Journal of AIDS & Clinical Research

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