alexa [Effect of arecoline on the differentiation of myofibroblasts of oral mucosa].
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Li X, Ling TY, Gao YJ

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Abstract OBJECTIVE: To investigate the origin of myofibroblasts in oral submucous fibrosis. METHODS: The oral keratinocytes and fibroblasts were isolated and cultured. The expression of the alpha-smooth muscle actin in the fibroblasts was examined by immunohistochemistry and reverse transcriptase polymerase chain reaction (RT-PCR). RESULTS: No difference was found in expression of alpha-smooth muscle actin between the fibroblasts that were directly stimulated by arecoline and the control. The expression of alpha-smooth muscle actin in the keratinocyte and fibroblast-cocultured group was higher than in the control group, and higher in fibroblasts cocultured with keratinocytes preprocessed by arecoline than in fibroblasts cocultured with keratinocytes without preprocessed by arecoline. CONCLUSIONS: The differentiation of myofibroblasts from fibroblasts in oral submucous fibrosis might be induced by the interaction of arecoline and keratinocyte.
This article was published in Zhonghua Kou Qiang Yi Xue Za Zhi and referenced in Journal of Cytology & Histology

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