alexa Effect of clonidine and dexmedetomidine premedication on perioperative oxygen consumption and haemodynamic state.


Journal of Hypertension: Open Access

Author(s): Taittonen MT, Kirvel OA, Aantaa R, Kanto JH

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Abstract Premedication has been shown to affect both oxygen consumption and metabolic rate. We have compared the perioperative metabolic and haemodynamic effects of two alpha 2-agonists, clonidine and the more selective dexmedetomidine, in 30 ASA I patients undergoing plastic surgical procedures under general anaesthesia. Patients were premedicated with clonidine 4 micrograms kg-1 (n = 10), dexmedetomidine 2.5 micrograms kg-1 (n = 10) or saline (n = 10) i.m. The doses of clonidine and dexmedetomidine were intended to be equipotent. The maximum decrease in preoperative oxygen consumption was 8\% and decreases in systolic and diastolic arterial pressures were 11\% from baseline after clonidine and dexmedetomidine. During operation, the maximum reduction in heart rate was 18\% in the clonidine and dexmedetomidine groups compared with the placebo group. After operation, the maximum decrease in systolic arterial pressure was 11\%, diastolic arterial pressure 15\% and oxygen consumption 17\% in the clonidine and dexmedetomidine groups compared with placebo. In summary, both clonidine 4 micrograms kg-1 and dexmedetomidine 2.5 micrograms kg-1 decreased perioperative oxygen consumption effectively, with a similar haemodynamic profile.
This article was published in Br J Anaesth and referenced in Journal of Hypertension: Open Access

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