alexa Effect of contraceptive steroids on serum levels of sex hormone binding globulin and caeruloplasmin.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Bioequivalence & Bioavailability

Author(s): Limpongsanurak S, Jenkins N, Fotherby K

Abstract Share this page

Abstract Serum sex hormone binding globulin and caeruloplasmin levels were measured in women receiving 30 microgram or 50 microgram ethinyl oestradiol daily or a 'triphasic' formulation containing ethinyl oestradiol and levonorgestrel. In women taking ethinyl oestradiol alone, there was a rapid increase in the levels of both proteins, and even 10 days after the last tablet the levels were still elevated. There was no significant difference between the serum levels of the proteins in women receiving the two doses of ethinyl oestradiol, but the percentage change was significantly higher in the 50 microgram group than in the 30 microgram group. In women using the 'triphasic' formulation, levels of the proteins were significantly lower than in women taking ethinyl oestradiol alone. There was a marked variation between women in the changes produced. This marked inter-subject variation may be important in the development of side-effects in women using steroidal contraceptives. PIP: Clinical research was conducted with human volunteers to ascertain the effect on serum levels of 2 proteins of hepatic origin--SHBG (sex hormone binding globulin) and CP (caeruloplasmin)--of 30 mcg and 50 mcg ethinyl estradiol administered alone and the new "triphasic" formulation consisting of low doses of ethinyl estradiol and levonorgestrel. Ethinyl estradiol caused a rapid increase in the mean levels of both SHBG and CP, which showed up as early as 2-3 days after initiation of the therapy and continued beyond the time of the therapy. Even the lower dose of ethinyl estradiol caused elevation of the 2 protein levels. Even the low dose of levonorgestrel present in the "triphasic" regimen had a sufficient antiestrogenic effect to prevent marked increase in both SHBG and CP. There were no significant differences in serum levels of the proteins in the women receiving the 30 mcg or the 50 mcg dosages. However, in any individual woman, the changes occurring with 30 mcg would be less than those occurring with 50 mcg. The study showed that there are marked inter-subject variations in metabolic changes occurring as a result of exposure to steroidal contraceptives. This article was published in Curr Med Res Opin and referenced in Journal of Bioequivalence & Bioavailability

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords