alexa Effect of distal graft anastomosis site on retrograde perfusion and flow patterns of native coronary vasculature.
General Science

General Science

Journal of Forensic Biomechanics

Author(s): Guo LR, Steinman DA, Moon BC, Wan WK, Millsap RJ

Abstract Share this page

Abstract BACKGROUND: To select the site of a target vessel for distal anastomosis surgeons use different approaches. Some try to place the graft as close to the stenosis as possible, whereas others routinely anastomose the graft onto the distal portion. In this latter case the proximal portion and its tributaries are perfused from the graft in a retrograde rather than an antegrade fashion. The aim of this study was to investigate the effect of local hemodynamics associated with the different location of distal anastomoses on flow patterns in the proximal native artery and its branches. METHODS: Computational fluid dynamic and in vitro model studies were carried out in a control model composed of a straight tube (host) with a 45E side branch and models in which the proximal end of the host had various degrees of stenosis; a 45E end-to-side "graft" anastomosis was introduced either proximal (upstream) or distal (downstream) to the branch. RESULTS: Placing the graft proximal to the branch largely preserved the flow patterns that were seen in the control model. Placing the graft distal to the branch, however, introduced an extensive region of relatively stagnant flow in the native vessel near the branch. Such regions are known to promote thrombus formation that could ultimately lead to occlusion of the retrograde portion of the host vessel. CONCLUSIONS: This study suggests that, although often less convenient surgically, long-term outcome of coronary artery bypass grafting may be improved by placing grafts in the most proximal portion of the native vessel, as close to the occlusion or stenosis as possible for better preservation of a proximal artery and its branches.
This article was published in Ann Thorac Surg and referenced in Journal of Forensic Biomechanics

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version