alexa Effect of dose on the frequency of major birth defects following fetal exposure to lamotrigine monotherapy in an international observational study.
Pediatrics

Pediatrics

Journal of Neonatal Biology

Author(s): Cunnington M, Ferber S, Quartey G International

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Abstract Data from the International Lamotrigine Pregnancy Registry were analyzed to examine the effect of maximal first-trimester maternal dose of lamotrigine monotherapy on the risk of major birth defects (MBDs). Among 802 exposures, the frequency of MBDs was 2.7\% (95\% confidence interval [CI] 1.8-4.2\%). The distribution of dose did not differ between infants with and those without MBDs (mean 248.3 milligrams per day [mg/day] and 278.9 mg/day, respectively, median 200 mg/day for both groups). A logistic regression analysis showed no difference in the risk of MBDs as a continuous function of dose (summary odds ratio [OR] per 100 mg increase =0.999, 95\% CI 0.996-1.001). There was also no effect of dose, up to 400 mg/day, on the frequency of MBDs. This article was published in Epilepsia and referenced in Journal of Neonatal Biology

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