alexa [Effect of erythropoietin therapy on serum lipoprotein levels in patients on hemodialysis].
Nephrology

Nephrology

Journal of Nephrology & Therapeutics

Author(s): Kes P, Bobi I, Reiner Z, RatkoviGusi I

Abstract Share this page

Abstract Disturbed lipoprotein metabolism is a well-documented feature in hemodialysis (HD) patients, and lipoprotein disturbances have been clearly linked to premature cardiovascular disease. The aim of this prospective study was to evaluate whether recombinant human erythropoietin (rHuEpo) therapy affects lipid metabolism. The study was performed in 40 chronic HD patients treated for three years with rHuEpo subcutaneously at the end of each dialysis session. Target hemoglobin (Hb) was 110 g/L. The control group consisted of 20 matched HD patients not treated with rHuEpo. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apolipoprotein A1 and B as well as lipoprotein (a) were assessed at baseline (without rHuEpo) and at months 6, 12, 18, 24, 30 and 36. In rHuEpo treated group a significant decrease in total cholesterol (6.05 +/- 1.0 vs. 5.15 +/- 0.6 mmol/L; p < 0.05), LDL-cholesterol (3.5 +/- 0.5 vs. 3.08 +/- 0.4 mmol/L; p < 0.05), apoprotein B (1.17 +/- 0.07 vs. 1.12 +/- 0.06 g/L; p < 0.05) and serum triglycerides (2.37 +/- 0.6 vs. 2.0 +/- 0.4 mmol/L; p < 0.05) and a significant increase in HDL-cholesterol (0.88 +/- 0.2 vs. 1.08 +/- 0.2 mmol/L; p < 0.05) occurred during the study. The improvement in each of the lipid parameters correlated significantly (p < 0.05) with the increase in Hb. It could be concluded that long-term rHuEpo treatment is associated with an improvement in the lipid profile. These results suggest that the high incidence of cardiovascular diseases in HD patients might be reduced with rHuEpo therapy.
This article was published in Lijec Vjesn and referenced in Journal of Nephrology & Therapeutics

Relevant Expert PPTs

Recommended Conferences

  • 15th International Conference on Nephrology & Therapeutics
    August 28-30, 2017 Philadelphia, USA
  • 16th European Nephrology Conference
    October 02-04, 2017 Barcelona, Spain
  • 16th European Nephrology Conference
    October 02-04, 2017 Barcelona, Spain
  • World Nephrology Congress
    Osaka, Japan Oct 09-11, 2017
  • 13th World Nephrology Conference
    October 18-19, 2017 Dubai,UAE
  • 16th International Conference on Nephrology
    NOVEMBER 02-03, 2017 Atlanta, USA

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords