alexa Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats.


Journal of Drug Metabolism & Toxicology

Author(s): Muramatsu K, Fukuyo M, Hara Y

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Abstract Effects of tea catechins (tannins) on lipid metabolism were studied in male weanling rats fed a 25\% casein diet containing 15\% lard and 1\% cholesterol for 28 days. Crude tea catechins prepared from green tea powder were supplemented at a 1\% and 2\% of the lard-cholesterol diet. The addition of 2\% tea catechins slightly depressed growth but at the 1\% level was without effect. Tea catechins decreased plasma total cholesterol, cholesterol ester, total cholesterol--HDL-cholesterol (VIDL-+LDL-cholesterol) and atherogenic index (VLDL-+LDL-cholesterol/HDL-cholesterol). Hematocrit and plasma glucose were not altered by the addition of tea catechins. The liver weight, liver total lipids and cholesterol concentrations in rats fed the lard-cholesterol diet increased more than in the control rats, but the addition of tea catechins to the lard-cholesterol diet decreased those parameters. Tea catechin supplementation increased fecal excretion of total lipids and cholesterol. The results demonstrate that tea catechins exert a hypocholesterolemic effect in cholesterol-fed rats.
This article was published in J Nutr Sci Vitaminol (Tokyo) and referenced in Journal of Drug Metabolism & Toxicology

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