alexa Effect of Mg2SO4 usage on spinal cord ischemia-reperfusion injury: electron microscopic and functional evaluation.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Kaplan S, Ulus AT, Ttn U, Aksyek A, Ozgencil E,

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Abstract OBJECTIVES: To evaluate the effects of intravenous magnesium sulfate (Mg(2)SO(4)) administration on ischemia-reperfusion injury of the spinal cord. MATERIAL AND METHODS: Sixteen rabbits were randomly assigned to the control (group I, 8 rabbits) and the study group (group II, 8 rabbits). The abdominal aorta was clamped for a period of 30 min followed by a reperfusion period of 60 min. The animals in group II received 0.25 ml/kg/h Mg(2)SO(4) intravenous infusion (15\% Mg(2)SO(4)) throughout this procedure. The animals were then observed for 24 h after which their neurological states were evaluated and tissue samples obtained from the spinal cord were examined with electron microscopy. RESULTS: Aortic pressure distal to the cross-clamp during the occlusion period was 9 +/- 3 mm Hg in group I and 19 +/- 6 mm Hg in group II. All animals in group I were paraplegic at the end of the study. In group II the neurological outcome of 1 animal was poor while the other 7 animals were neurologically in a good condition. Electron microscopic examinations of the spinal cord tissues of group I revealed severe injury but the ultrastructure was well preserved in group II. CONCLUSIONS: Intravenous Mg(2)SO(4) administration may have protective effects on the ischemia-reperfusion injury of the spinal cord. We propose that Mg(2)SO(4) may be an additional protective pharmacological agent in thoracal and thoracoabdominal aortic surgery. Copyright 2004 S. Karger AG, Basel This article was published in Eur Surg Res and referenced in Journal of Addiction Research & Therapy

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