Author(s): Fan LL, Li J, Sun LH
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Abstract The present study was carried out on rat heart to in situ determine the myocardial toxicity of moniliformin, a synthesized compound, originally isolated from mouldy corn and soil samples in the Keshan disease prevalent area in China. Perfusion of moniliformin 10(-7) mol/liter in isolated heart decreased myocardial contractile force by 52 +/- 17\%. Intravenous injection of moniliformin at 1/6 and 1/4 LD50 markedly inhibited cardiac hemodynamic variables relative to myocardial contractile function. Particularly, it decreased +/- LV dP/dt max by 52 +/- 6\%, and induced ventricular arrhythmia. These data indicate that moniliformin is toxic to mammalian heart and might be an important factor relative to Keshan disease.
This article was published in Biomed Environ Sci
and referenced in Journal of Biomolecular Research & Therapeutics