Author(s): Ahmed BA, Kakroo S, Jan NA, Ahmed DB, Ahmad SF
Sixty patients were studied to find out the effect of oral clonidine premedication on sedation and anxiety in patients undergoing trans-urethral resection of prostrate (TURP) under spinal anaesthesia with 5 percent Lidocaine. The patients were all males and of ASA physical status II in the age range of 50-70 years. Patients were randomly allocated to study group & control group consisting of 30 patients each. 150mg of oral clonidine was compared with a placebo given orally 90 minutes before lidocaine spinal anaesthesia in this double blind study. Anxiolysis was assessed by a 100 mm visual Analogue Scale (VAS) and sedation was assessed by a four point scale. Clonidine produced significant anxiolysis before and during spinal anaesthesia (p<0.001) Clonidine also produced grade II sedation in significant number of patients (33.33 percent) during spinal anaesthesia and in the post-operative period (p<0.25, <0.01 respectively).