alexa Effect of reduced training and training cessation on insulin action and muscle GLUT-4.
Gastroenterology

Gastroenterology

Journal of Liver

Author(s): Houmard JA, Tyndall GL, Midyette JB, Hickey MS, Dolan PL, , Houmard JA, Tyndall GL, Midyette JB, Hickey MS, Dolan PL,

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Abstract This study examined the impact of a 50\% reduction in training frequency or training cessation on insulin action and muscle GLUT-4 protein concentration. Middle-aged individuals were tested before and after 12 wk of exercise training (4 days/wk, 40-45 min/day). Subjects then either maintained training (n = 9), reduced training frequency by 50\% (n = 11), or stopped exercising (n = 10) for the ensuing 2 wk. GLUT-4 protein concentration and insulin action (insulin sensitivity index, as determined by the minimal model) increased (P < or = 0.05) by an average of 1.6- and 1.9-fold, respectively, with the 12 wk of training. Insulin action and GLUT-4 did not increase further with the additional 2 wk of training in the maintained training group. Similarly, insulin sensitivity index and GLUT-4 concentration remained at trained levels when training frequency was reduced by 50\% for 2 wk. GLUT-4 concentration and insulin action, however, were not different from sedentary values after 14 days of training cessation. These findings indicate that a 14-day 50\% reduction in exercise frequency maintains the improvements in GLUT-4 protein concentration and insulin action gained with endurance training in moderately trained middle-aged adults; in contrast, these adaptations are largely lost with training cessation.
This article was published in J Appl Physiol (1985) and referenced in Journal of Liver

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