Author(s): Lukhanina EP, Kolomiets BP, Pilkevich NA
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Abstract Modulatory influence of beta1- and beta2-subtypes of adrenergic receptors (ARs) on the background neuronal activity and cerebellocortical transmission was characterized in the rat primary motor cortex (M1). Microiontophoretic administration of non-selective beta-ARs agonist isoproterenol significantly decreased firing rate and responses to superior cerebellar peduncle stimulation in 82\% of studied neurons in a dose-dependent manner. Similar changes were induced by ejection of selective beta1-ARs agonist dobutamine, while fenoterol (selective beta2-ARs agonist) increased or reduced firing rate in 32\% and 19\% of M1 neurons, respectively. Non-selective beta-ARs antagonist propranolol enhanced both the background and evoked activity in 84\% of tested neurons. These data provided the functional evidence for beta-ARs-mediated inhibition (predominantly through beta1-subtype) of cerebellocortical input to M1. The possible mechanism of the positive therapeutic effect of propranolol in tremor-predominant Parkinson's disease is discussed. Copyright 2003 Elsevier Science Ireland Ltd.
This article was published in Neurosci Lett
and referenced in Journal of Alzheimers Disease & Parkinsonism