alexa Effect of stimulation of beta-adrenergic receptors on neuronal activity in primary motor cortex of the rat.


Journal of Alzheimers Disease & Parkinsonism

Author(s): Lukhanina EP, Kolomiets BP, Pilkevich NA

Abstract Share this page

Abstract Modulatory influence of beta1- and beta2-subtypes of adrenergic receptors (ARs) on the background neuronal activity and cerebellocortical transmission was characterized in the rat primary motor cortex (M1). Microiontophoretic administration of non-selective beta-ARs agonist isoproterenol significantly decreased firing rate and responses to superior cerebellar peduncle stimulation in 82\% of studied neurons in a dose-dependent manner. Similar changes were induced by ejection of selective beta1-ARs agonist dobutamine, while fenoterol (selective beta2-ARs agonist) increased or reduced firing rate in 32\% and 19\% of M1 neurons, respectively. Non-selective beta-ARs antagonist propranolol enhanced both the background and evoked activity in 84\% of tested neurons. These data provided the functional evidence for beta-ARs-mediated inhibition (predominantly through beta1-subtype) of cerebellocortical input to M1. The possible mechanism of the positive therapeutic effect of propranolol in tremor-predominant Parkinson's disease is discussed. Copyright 2003 Elsevier Science Ireland Ltd.
This article was published in Neurosci Lett and referenced in Journal of Alzheimers Disease & Parkinsonism

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version