alexa Effect of voriconazole on a corneal abscess caused by fusarium.


Journal of Clinical & Cellular Immunology

Author(s): Polizzi A, Siniscalchi C, Mastromarino A, Sacc SC

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Abstract PURPOSE: To describe a case of corneal abscess caused by Fusarium solani that did not respond to common antifungal agents. METHOD: Case report. RESULTS: Twenty days after accidental contact with vegetation, a 56-year-old man presented with a corneal abscess. Corneal ulceration developed and a perforating keratoplasty was performed. After a microbiological examination, the diagnosis of F. solani infection was made. Systemic and topical amphotericin B and fluconazole were prescribed, with no results. A new abscess formed on the transplanted graft and a wound leak developed. We administered topical and systemic voriconazole. No side-effects were observed. The choroidal detachment and the surgical transplant recovered completely in 20 days. A vascular leukoma developed at the site of the transplanted corneal abscess. CONCLUSION: From a functional point of view, another corneal transplant will be necessary. Voriconazole was effective in treating a severe keratomycosis caused by F. solani that was resistant to other topical and systemic antifungal agents. This article was published in Acta Ophthalmol Scand and referenced in Journal of Clinical & Cellular Immunology

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