alexa Effect on cardiac function of altered adenosine metabolism in rat brain structures in modelled hyperuricemia


Research & Reviews: Journal of Food and Dairy Technology

Author(s): Barinov EF, Grin VK, Siniachenko OV, Bondarenko NN

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Experiments on 24 Wistar male rats were performed to clarify the role of central mechanisms in the onset of electrical instability of the heart due to disturbances in purine metabolism. The activity of the enzymes responsible for synthesis and conversion of adenosine-5-nucleotidase and adenosine deaminase in the sensomotor cortex, hypothalamus and hippocamp was studied. Changes in cardiac function were most severe in high levels of adenosine in the neurons of the sensomotor cortex, hypothalamus and hippocamp. Minimal changes occurred in low content of adenosine in the hypothalamus and hippocamp.

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This article was published in Patol Fiziol Eksp Ter and referenced in Research & Reviews: Journal of Food and Dairy Technology

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