Author(s): Huber M, Timms E, Mak TW, Rllinghoff M, Lohoff M, Huber M, Timms E, Mak TW, Rllinghoff M, Lohoff M
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Abstract The results of earlier investigations that tested whether CD8(+) T cells are required in the defense against Leishmania major have been inconsistent. We used CD8-deficient mice to directly address this issue. After primary infection with L. major, CD8-deficient mice controlled the infection for over 1 year and mounted strong T helper 1 cell responses. Thus, CD8(+) T cells are not required for the long-term control of a primary infection with L. major.
This article was published in Infect Immun
and referenced in Journal of Microbial & Biochemical Technology