Author(s): Anitua E, Aguirre JJ, Algorta J, Ayerdi E, Cabezas AI,
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Abstract Autologous Preparation Rich in Growth Factors (PRGF), a small volume of plasma enriched in platelets, is a novel therapeutic strategy for the acceleration of the wound healing of a wide range of tissues because of the continuous release of multiple growth factors, including PDGF-AB, TGF-beta1, IGF-I, HGF, VEGF-A, and EGF. In this article, we have characterized the PRGF preparation and designed a randomized open-label controlled pilot trial to evaluate the effectiveness of PRGF in the treatment of chronic cutaneous ulcers. Results showed that at 8 weeks, the mean percentage of surface healed in the PRGF group was 72.94\% +/- 22.25\% whereas it was 21.48\% +/- 33.56\% in the control group (p < 0.05). These results, with the limitations of a pilot study, suggest that topical application of PRGF is more effective than standard therapy in helping a chronic ulcer to heal. (c) 2007 Wiley Periodicals, Inc.
This article was published in J Biomed Mater Res B Appl Biomater
and referenced in Journal of Blood Disorders & Transfusion