Author(s): Castilla J, Beristain X, MartnezArtola V, Navascus A, Garca Cenoz M,
Abstract Share this page
Abstract Two rotavirus vaccines have been available since 2006. This study evaluates the effectiveness of these vaccines using a test-negative case-control design in Navarre, Spain. We included children 3-59 months of age who sought medical care for gastroenteritis and for whom stool samples were taken between January 2008 and June 2011. About 9\% had received the pentavalent vaccine (RotaTeq) and another 8\% received the monovalent vaccine (Rotarix). Cases were the 756 children with confirmed rotavirus and controls were the 6036 children who tested negative for rotavirus. Thirty-five percent of cases and 9\% of controls had required hospitalization (p<0.0001). The adjusted effectiveness of complete vaccination was 78\% (95\% CI: 68-85\%) in preventing rotavirus gastroenteritis and 83\% (95\% CI: 65-93\%) in preventing hospitalization for rotavirus gastroenteritis. No differences between the two vaccines were detected (p=0.4523). Both vaccines were highly effective in preventing cases and hospital admissions in children due to rotavirus gastroenteritis. Copyright © 2011. Published by Elsevier Ltd.
This article was published in Vaccine
and referenced in Journal of Vaccines & Vaccination