alexa Effects of acute thyroxin depletion on hearing in humans.


Otolaryngology: Open Access

Author(s): Mra Z, Wax MK

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Abstract OBJECTIVE: To study the physiologic effect of acute thyroid hormone depletion on hearing and the function of outer hair cells. DESIGN: Audiologic and otoacoustic emission testing of subjects undergoing total thyroidectomy before surgery and up to 6 weeks after surgery. Magnitude of thyroxin depletion monitored by serum thyroid-stimulating hormone levels. SETTING: Hearing research laboratory at a state university. SUBJECTS: Ten patients undergoing total thyroidectomy. MAIN OUTCOME MEASURES: Detection of hearing loss on audiogram and decrease or disappearance of otoacoustic emissions as a result of acute thyroxin depletion. RESULTS: No significant changes in the audiogram and otoacoustic emission configurations were detected, although thyroid-stimulating hormone levels became elevated after total thyroidectomy. CONCLUSION: Although thyroid hormone is thought to play a role in the physiology of hearing in humans, no deleterious effects on hearing can be identified up to 6 weeks after thyroxin depletion.
This article was published in Laryngoscope and referenced in Otolaryngology: Open Access

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