alexa Effects of alpha-substitutions on structure and biological activity of anticancer chalcones.


Chemical Sciences Journal

Author(s): Lawrence NJ, Patterson RP, Ooi LL, Cook D, Ducki S

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Abstract Chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerisation. We describe here the effects of different alpha-substitutions, in particular alpha-fluorination, on the structure and biological activity of a series of chalcones. This article was published in Bioorg Med Chem Lett and referenced in Chemical Sciences Journal

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